Biochemical changes after spontaneous subarachnoid haemorrhage. I. The biochemical problem.

Biochemical changes after spontaneous subarachnoid haemorrhage. 3. Coagulation and lysis with special reference to recurrent haemorrhage.

Lumbar puncture in spontaneous subarachnoid haemorrhage.

Seventy-four patients with proved spontaneous subarachnoid haemorrhage were studied. Sixty-four underwent computed tomography and 55 underwent lumbar puncture. Seven cases deteriorated dramatically after lumbar puncture, six of these showing evidence of cerebral dislocation on further investigation. Four of the seven had not undergone computed tomography and three underwent computed tomography ...

Haemoglobin scavenging after subarachnoid haemorrhage.

Rapid and effective clearance of cell-free haemoglobin after subarachnoid haemorrhage (SAH) is important to prevent vasospasm and neurotoxicity and improve long-term outcome. Haemoglobin is avidly bound by haptoglobin, and the complex is cleared by CD163 expressed on the membrane surface of macrophages. We studied the kinetics of haemoglobin and haptoglobin in cerebrospinal fluid after SAH. We ...

Chemical and biochemical oxidations in spinal fluid after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) is a stroke with high rates of mortality and morbidity. SAH-induced cerebral vasospasm can lead to ischemic injury or death and is a common complication of SAH. Recently there has been an accumulation of emerging evidence that oxidation of heme-derived bilirubin into bilirubin oxidation products (BOXes) may be involved in cerebral vasospasm. BOXes are produced by t...

Electrolyte changes in patients with subarachnoid haemorrhage.

1. After spontaneous subarachnoid haemorrhage in man there is an acute rise in arterial blood pressure. Sodium balance studies were carried out on sixty-four patients with this syndrome and marked sodium retention was found to occur which did not appear to be correlated with a low glomerular filtration rate nor with any consistent change in aldosterone excretion. 2. Effective renal plasma flow ...